A01 : Living body's dependence on gravity; the study of plasticity and collapse mechanisms - Publications

Original Articles

  1. 2019
  2. 2018
  3. 2017
  4. 2016
  5. 2015

2019

  • Biological Effects of Anti-RANKL Antibody and Zoledronic Acid on Growth and Tooth Eruption in Growing Mice, Motoki Isawa, *Akiko Karakawa, Nobuhiro Sakai, Saki Nishina, Miku Kuritani, Masahiro Chatani, Takako Negishi-Koga, Masashi Sato, Mitsuko Inoue, Yukie Shimada, and Masamichi Takami , Scientific Reports, 9, 19895, 2019, 12, https://doi.org/10.1038/s41598-019-56151-1
  • Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate, *Arai HN, Sato F,Yamamoto T, Woltjen K, Kiyonari H, Yoshimoto Y, Shukunami C, Akiyama H, Kist R, *Sehara-Fujisawa A, Cell Reports, 29, 603-616, 2019, 10, https://doi.org/10.1016/j.celrep.2019.09.019
  • A bidirectional network for appetite control in larval zebrafish, Caroline Lei Wee, Erin Yue Song, Robert Evan Johnson, Deepak Ailani, Owen Randlett, Ji-Yoon Kim, Maxim Nikitchenko, Armin Bahl, Chao-Tsung Yang, Misha B Ahrens, Koichi Kawakami, Florian Engert, Sam Kunes, eLIFE, 8, e43775, 2019, 10, doi:10.7554/eLife.43775
  • Male mice, caged in the International Space Station for 35 days, sire healthy offspring., Matsumura T, Noda T, Muratani M, Okada R, Yamane M, Isotani A, Kudo T, Takahashi S, *Ikawa M., Sci Rep., 9(1), 13733, 2019, 9, doi:10.1038/s41598-019-50128-w
  • Mitochondrial dysfunction causes Ca2+ overload and ECM degradation-mediated muscle damage in C. elegans., Sudevan S, Takiura M, Kubota Y, Higashitani N, Cooke M, Ellwood RA, Etheridge T, Szewczyk NJ, Higashitani A., FASEB J., 33, 9540-9550, 2019, 8, doi:10.1096/fj.201802298R.
  • Neural signatures of sleep in zebrafish, Louis C Leung, Gordon X Wang, Romain Madelaine, Gemini Skariah, Koichi Kawakami, Karl Deisseroth, Alexander E Urban, and Philippe Mourrain, Nature, 571, 198-204, 2019, 7, https://doi.org/10.1038/s41586-019-1336-7
  • The L-type amino acid transporter LAT1 inhibits osteoclastogenesis and maintains bone homeostasis through the mTORC1 pathway., Ozaki K, Yamada T, Horie T, Ishizaki A, Hiraiwa M, Iezaki T, Park G, Fukasawa K, Kamada H, Tokumura K, Motono M, Kaneda K, Ogawa K, Ochi H, Sato S, Kobayashi Y, Shi YB, Taylor PM, Hinoi E., Sci Signal., 12, eaaw3921, 2019, 7, doi:10.1126/scisignal.aaw3921
  • TRPC6 regulates phenotype switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN , Takuro Numaga-Tomita, Tsukasa Shimauchi, Sayaka Oda, Tomohiro Tanaka, Kazuhiro Nishiyama, Akiyuki Nishimura, Lutz Birnbaumer, Yasuo Mori and Motohiro Nishida, FASEB J, ー, ー, 2019, 6, https://doi.org/10.1096/fj.201802811R
  • Down-regulation of GATA1-dependent erythrocyte-related genes in the spleens of mice exposed to a space travel., Kenta Horie, Hiroki Sasanuma, Takashi Kudo, Shin-ichiro Fujita, Maki Miyauchi, Takahisa Miyao, Takao Seki, Nobuko Akiyama, Yuki Takakura, Miki Shimbo, Hyojung Jeon, Masaki Shirakawa, Dai Shiba, Nobuaki Yoshida, Masafumi Muratani, Satoru Takahashi & Taishin Akiyama , Scientific Report, 9, 7654, 2019, 5, doi:10.1038/s41598-019-44067-9
  • PDH-mediated metabolic flow is critical for skeletal muscle stem cell differentiation and myotube formation during regeneration inmice., Hori S, Hiramuki Y, Nishimura D, Sato F, Sehara-Fujisawa A., FASEB Journal, 33, TBD, 2019, 4, doi:10.1096/fj.201802479R
  • Six6 and Six7 coordinately regulate expression of middle-wavelength opsins in zebrafish, Yohey Ogawa, Tomoya Shiraki, Yoshimasa Asano, Akira Muto, Koichi Kawakami, Yutaka Suzuki, Daisuke Kojima, Yoshitaka Fukada, Proceedings of the National Academy of Sciences, 116, 4651-4660, 2019, 3, https://doi.org/10.1073/pnas.1812884116
  • Aqueous/Aqueous Micro Phase Separation: Construction of an Artificial Model of Cellular Assembly, Hiroki Sakuta, Tadashi Fujimoto, Yusuke Yamana, Yusuke Hoda, Kanta Tsumoto, Kenichi Yoshikawa, Frontiers in Chemistry, 7, 44 (7 pages), 2019, 2, doi:10.3389/fchem.2019.00044

2018

  • A tRNA-based multiplex sgRNA expression system in zebrafish and its application to generation of transgenic albino fish , Tomoya Shiraki, Koichi Kawakami , Scientific reports, 8, 13366, 2018, 9, doi:10.1038/s41598-018-31476-5
  • Translational Control of Sox9 RNA by mTORC1 Contributes to Skeletogenesis., Iezaki T, Horie T, Fukasawa K, Kitabatake M, Nakamura Y, Park G, Onishi Y, Ozaki K, Kanayama T, Hiraiwa M, Kitaguchi Y, Kaneda K, Manabe T, Ishigaki Y, Ohno M, Hinoi E., Stem Cell Reports. , 11, 228-241, 2018, 7, doi:10.1016/j.stemcr.2018.05.020
  • The MAPK Erk5 is necessary for proper skeletogenesis involving a Smurf-Smad-Sox9 molecular axis., Iezaki T, Fukasawa K, Horie T, Park G, Robinson S, Nakaya M, Fujita H, Onishi Y, Ozaki K, Kanayama T, Hiraiwa M, Kitaguchi Y, Kaneda K, Yoneda Y, Takarada T, Guo XE, Kurose H, Hinoi E., Development., 145, ?, 2018, 7, doi:10.1242/dev.164004
  • Protocadherin-Mediated Cell Repulsion Controls the Central Topography and Efferent Projections of the Abducens Nucleus , Kazuhide Asakawa, Koichi Kawakami , Cell reports, 24, 1562-1572, 2018, 7, doi:10.1016/j.celrep.2018.07.024
  • TRPC5-eNOS axis negatively regulates ATP-induced cardiomyocyte hypertrophy, Sunggip C., Shimoda K., Oda S., Tanaka T., Nishiyama K., Mangmool S., Nishimura A., Numaga-Tomita T. and *Nishida M. ,Front. Pharmacol, Front Pharmacol. 2018; 9: 523 ,Published online 2018 May 22. doi:10.3389/fphar.2018.00523
  • Anti-mouse RANKL Antibodies Inhibit Alveolar Bone Destruction in Periodontitis Model Mice, Kuritani M, Sakai N, Karakawa A, Isawa M, Chatani M, Negishi-Koga T, Funatsu T, Takami M. Biol Pharm Bull. 2018;41(4):637-643. doi: 10.1248/bpb.b18-00026.
  • Reactive oxygen species upregulate expression of muscle atrophy-associated ubiquitin ligase Cbl-b in rat L6 skeletal muscle cells. , Takayuki Uchida, Yoshihiro Sakashita, Kanako Kitahata, Yui Yamashita, Chisato Tomida, Yuki Kimori, Akio Komatsu, Katsuya Hirasaka, Ayako Ohno, Reiko Nakao, Atsushi Higashitani, Akira Higashibata, Noriaki Ishioka, Toru Shimazu, Takeshi Kobayashi, Yuushi Okumura, Inho Choi, Motoko Oarada, Edward M. Mills, Shigetada Teshima-Kondo, Shin’ichi Takeda, Eiji Tanaka, Keiji Tanaka, Masahiro Sokabe, Takeshi Nikawa, Am J Physiol Cell Physiol, Vol.314:6, C721-731, Vol.8 No.1, February 2018, doi:10.1152/ajpcell.00184.2017
  • Identification of a neuronal population in the telencephalon essential for fear conditioning in zebrafish. Lal, P., Tanabe, H., Suster, M.L., Ailan, D., Kotani, Y., Muto, A., Itoh, M., Iwasaki, M., Wada, H., Yaksi, E., and Kawakami, K. , BMC Biology, 16:45,2018.
  • VEGF pathway-targeting drugs induce evasive adaptation by activation of neuropilin-1/cMet in colon cancer cells. Chisato Tomida, Naoko Yamagishi, Hikaru Nagano, Takayuki Uchida, Ayako Ohno, Katsuya Hirasaka, Takeshi Nikawa, Shigetada Teshima- Kondo, Int J of Oncol, Published online on: February 28, 2018 https://doi.org/10.3892/ijo.2018.4291, Pages:1350-1362
  • Distinct gene expression profile distinguishes increased metabolic activity in spontaneously hyperactive rats while sedentary from that induced by exercise. Manami Abe, Yuki Matsuo, Akiko Harada-Sukeno, Takayuki Uchida, Kanako Kitahata, Chisato Tomida, Katsuya Hirasaka, Shigetada Teshima-Kondo, Nagakatsu Harada, Yutaka Nakaya, Hiroshi Sakaue, Reiko Nakao, Takeshi Nikawa, Adv Biol Sci, Advances in Biological Chemistry, 2018, 8, 1-14, doi:10.4236/abc.2018.81001

2017

  • TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice , Oda S., Numaga-Tomita T., Kitajima N., Toyama T., Harada E., Shimauchi T., Nishimura A., Ishikawa T., Kumagai Y., Birnbaumer L. and *Nishida M. Sci. Rep. 8, 7511, 2017, doi:10.1038/s41598-017-07903-4
  • TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy , Shimauchi T., Numaga-Tomita T., Ito T, Nishimura A., Matsukane R., Oda S., Hoka S., Ide T., Koitabashi N., Uchida K., Sumimoto H., Mori Y. and *Nishida M. JCI Insight 2, e93358, 2017 Aug 3; 2(15), doi: 10.1172/jci.insight.93358
  • Secretome analysis to elucidate metalloprotease-dependent ectodomain shedding of glycoproteins during neuronal differentiation. Tsumagari, K., Shirakabe, K., Ogura, M., Sato, F., Ishihama, Y. and Sehara-Fujisawa, A,Genes to Cells 22, 237-244, 2017, doi: 10.1111/gtc.12466. Epub 2017 Jan 13.
  • Upregulation of matrix metalloproteinase triggers transdifferentiation of retinal pigmented epithelial cells in Xenopus laevis: A link between inflammatory response and regeneration., Naitoh, H., Suganuma, Y., Ueda, Y., Sato, T., Hiramuki, Y., Fujisawa-Sehara, A., Taketani, S. and Araki, M, Developmental Neurobiology 77(9), 1086-1100, 2017
  • A novel perivascular cell population in the zebrafish brain., Galanternik, M.V., Castranova, D., Gore, A.V., Blewett, N.H., Jung, H.M., Stratton, A.N., Kirby, M.R., Iben, J., Miller, M.F., Kawakami, K., Maraia, R.J., and Weinstein B.M , eLife eLife.24369 (2017).
  • Antiangiogenic agent sunitinib induces epithelial to mesenchymal transition and accelerates motility of colorectal cancer cells, Tomida C, Yamagishi N, Nagano H, Uchida T, Ohno A, Hirasaka K, *Nikawa T, Teshima-Kondo S., J Med Invest. 2017;64(3.4):250-254. doi: 10.2152/jmi.64.250
  • Regorafenib induces adaptive resistance of colorectal cancer cells via inhibition of vascular endothelial growth factor receptor, Tomida C, Nagano H, Yamagishi N, Uchida T, Ohno A, Hirasaka K, *Nikawa T, Teshima-Kondo S, J Med Invest. 2017;64(3.4):262-265. doi: 10.2152/jmi.64.262.
  • Heat-induced calcium leakage causes mitochondrial damage in Caenorhabditis elegans body-wall muscles. , Momma K, Homma T, Isaka R, Sudevan S, Higashitani A. ,Genetics , Volume 206 Issue, August 2017, https://doi.org/10.1534/genetics.117.202747
  • Nutritional counseling effectively regulates inter-dialysis weight gain and blood pressure of maintenance hemodialysis outpatients. Sakai A, Hamada H, Hara K, Mori K, Mizuguchi T, Minaguchi J, Shima K, Kawashima S, Yamagata K, Okumura Y, Nikawa T. J Med Invest , Vol.64, 129-135pp, 2017
  • Altered KYN/TRP, Gln/Glu, and Met/methionine sulfoxide ratios in the blood plasma of medication-free patients with major depressive disorder, Hidehiro Umehara, Shusuke Numata, Shin-ya Watanabe, Yutaka Hatakeyama, Makoto Kinoshita, Yukiko Tomioka, Kiyoshi Nakahara, Takeshi Nikawa, Tetsuo Ohmori, Sci Rep,Scientific Reports 7, Article number: 4855, 2017, doi:10.1038/s41598-017-05121-6
  • Development and performance evaluation of a three-dimensional clinostat synchronized heavy-ion irradiation system. Ikeda H, Souda H, Puspitasari A, Held KD, Hidema J, Nikawa T, Yoshida Y, Kanai T, Takahashi A. Life Sci Space Res (Amst), 2017 Feb;12:51-60. doi:10.1016/j.lssr.2017.01.003. Epub 2017 Jan
  • Secretome analysis to elucidate metalloprotease-dependent ectodomain shedding of glycoproteins during neuronal differentiation. Tsumagari K, Shirakabe K, Ogura M, Sato F, Ishihama Y and Sehara-Fujisawa A., Genes to Cells 22, 237-244, doi:10.1111/gtc.12466, 2017
  • YAP is essential for 3D organogenesis withstanding gravity. ,Asaoka Y, Nishina H, Furutani-Seiki M. Dev Growth Differ. 59: 52-58, doi: 10.1111/dgd.12338, 2017
  • Activation of the hypothalamic feeding centre upon visual prey detection, Akira Muto, Pradeep Lal, Deepak Ailani, Gembu Abe, Mari Itoh, Koichi Kawakami, Nature Communications 8, Article number: 15029, doi:10.1038/ncomms15029, 2017

2016

  • Fluid dynamics alter Caenorhabditis elegans body length via TGF-β/DBL-1 neuromuscular signaling., Harada S, Hashizume T, Nemoto K, Shao Z, Higashitani N, Etheridge T, Szewczyk NJ, Fukui K, Higashibata A and Higashitani A. , npj Microgravity, 2: 16006, doi:10.1038/npjmgrav.2016.6, 2016
  • Microgravity elicits reproducible alterations in cytoskeletal and metabolic gene and protein expression in space-flown Caenorhabditis elegans, Akira Higashibata, Toko Hashizume, Kanako Nemoto, Nahoko Higashitani, Timothy Etheridge, Chihiro Mori, Shunsuke Harada, Tomoko Sugimoto, Nathaniel J Szewczyk, Shoji A Baba, Yoshihiro Mogami, Keiji Fukui & Atsushi Higashitani, npj Microgravity, 2: 15022 , doi:10.1038/npjmgrav.2015.22, 2016
  • Modulation of cutaneous extracellular collagen contraction by phosphorylation status of p130Cas. Takeya M, Okumura Y, Nikawa T. J Physiol Sci, Volume 67, Issue 5, pp 613-622, 2017(First Online: 07 October 2016)
  • 8-Prenylnaringenin promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice. Mukai R, Horikawa H, Lin PY, Tsukumo N, Nikawa T, Kawamura T, Nemoto H, Terao J. Am J Physiol Regul Integr Comp Physiol. 311(6):R1022-R1031.,2016
  • Dietary supplementation with isoflavones prevents muscle wasting in tumor-bearing mice. Hirasaka K, Saito S, Yamaguchi S, Miyazaki R, Wang Y, Haruna M, Taniyama S, Higashitani A, Terao J, Nikawa T, Tachibana K. J Nutr Sci Vitaminol (Tokyo). 62(3):178-84. 2016
  • Preventive effect of dietary quercetin on disuse muscle atrophy by targeting mitochondria in denervated mice. Mukai R, Matsui N, Fujikura Y, Matsumoto N, Hou DX, Kanzaki N, Shibata H, Horikawa M, Iwasa K, Hirasaka K, Nikawa T, Terao J. J Nutr Biochem. 31:67-76, 2016
  • Capric Acid Up-Regulates UCP3 Expression without PDK4 Induction in Mouse C2C12 Myotubes. Abe T, Hirasaka K, Kohno S, Tomida C, Haruna M, Uchida T, Ohno A, Oarada M, Teshima-Kondo S, Okumura Y, Choi I, Aoyama T, Terao J, Nikawa T. J Nutr Sci Vitaminol (Tokyo). 62(1):32-9, 2016
  • UCP3 is associated with Hax-1 in mitochondria in the presence of calcium ion. Hirasaka K, Mills EM, Haruna M, Bando A, Ikeda C, Abe T, Kohno S, Nowinski SM, Lago CU, Akagi K, Tochio H, Ohno A, Teshima-Kondo S, Okumura Y, Nikawa T. Biochem Biophys Res Commun. 472(1):108-13, 2016
  • TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling, Kitajima N., Numaga-Tomita T., Watanabe M., Kuroda T., Nishimura A., Miyano K., Yasuda S., Kuwahara K., Sato Y., Ide T, Birnbaumer L., Sumimoto H., Mori Y. and Nishida M,Scientific Reports 6:37001. doi: 10.1038/srep37001 ,2016
  • TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis,Numaga-Tomita T., Kitajima N., Kuroda T., Nishimura A., Miyano K., Yasuda S., Kuwahara K., Sato Y., Ide T., Birnbaumer L., Sumimoto H., Mori Y. and Nishida M, Scientific Reports 6:39383. doi:10.1038/srep39383, 2016
  • Acute transcriptional up-regulation specific to osteoblasts/osteoclasts in medaka fish immediately after exposure to microgravity, Chatani M, Morimoto H, Takeyama K, Mantoku A, Tanigawa N, Kubota K, Suzuki H, Uchida S, Tanigaki F, Shirakawa M, Gusev O, Sychev V, Takano Y, Itoh T, Kudo A, Sci Rep. 6: 39545, 2016, 1-14, doi:10.1038/srep39545.
  • ADAM12-deficient zebrafish exhibit retardation in body growth at the juvenile stage without developmental defects. ,Tokumasu Y, Iida A, Wang Z, Ansai S, Kinoshita M, and Sehara-Fujisawa A. Development, Growth & Differentation, 58(4):409-421, doi:10.1111/dgd.12286, 2016
  • Visualization of Neuregulin 1 ectodomain shedding reveals its local processing in vitro and in vivo, Kamezaki A, Sato F, Aoki K, Asakawa K, Kawakami K, Matsuzaki F, Sehara-Fujisawa A. . Scientific Rep., 6:28873, doi:10.1038/srep28873, 2016
  • Optimization of a neurotoxin to investigate the contribution of excitatory interneurons to speed modulation in vivo. Sternberg, J.R., Severi, K.E., Fidelin, K., Gomez, J., Ihara, H., Alcheikh, Y., Hubbard, J. M., Kawakami, K., Suster, M., and Wyatt, C. Current Biology 17, 2319-2328, 2016
  • Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies, Shimbo M, Kudo T, Hamada M, Jeon H, Imamura Y, Asano K, Okada R, Tsunakawa Y, Mizuno S, Yagami K, Ishikawa C, Li H, Shiga T, Ishida J, Hamada J, Murata K, Ishimaru T, Hashimoto M, Fukamizu A, Yamane M, Ikawa M, Morita H, Shinohara M, Asahara H, Akiyama T, Akiyama N, Sasanuma H, Yoshida N, Zhou R, Wang YY, Ito T, Kokubu Y, Noguchi TA, Ishimine H, Kurisaki A, Shiba D, Mizuno H, Shirakawa M, Ito N, Takeda S, Takahashi S, Experimental Animals. 65:175-187. doi: 0.1538/expanim.15-0077, 2016 (*本論文は掲載紙の表紙に選ばれた)
  • Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator, Nobuko Akiyama, Nobukazu Takizawa, Maki Miyauchi, Hiromi Yanai, Ryosuke Tateishi, Miho Shinzawa, Riko Yoshinaga, Masaaki Kurihara, Yosuke Demizu, Hisataka Yasuda, Shintaro Yagi, Guoying Wu, Mitsuru Matsumoto, Reiko Sakamoto, Nobuaki Yoshida, Josef M. Penninger, Yasuhiro Kobayashi, Jun‑ichiro Inoue, and Taishin Akiyama,, The Journal of Experimental Medicine, Vol. 213, No. 8, 1441–1458, Jul.11, 2016

2015

  • Molecular dynamics study on protein–water interplay in the mechanogating of the bacterial mechanosensitive channel MscL. , Sawada Y, Sokabe M, Eur J Biophys. 44 :531-43, doi:10.1007/s00249-015-1065-2. 2015
  • Unidirectional incorporation of a bacterial mechanosensitive channel into liposomal membranes, Nomura T, Cox CD, Bavi N, Sokabe M, Martinac B. FASEB J, 10: 4334-45, doi:10.1096/fj.15-275198.,2015
  • Ion Channels Activated by Mechanical Forces in Bacterial and Eukaryotic Cells. Subcell Biochem: High Pressure Bioscience - Basic Concepts, Sokabe M, Sawada Y, Kobayashi T., Applications and Frontiers. 72:613-26, doi:10.1007/978-94-017-9918-8_28. ,2015