低体温誘導の記憶へのリスクと可塑性- 公募研究 2018-2019

  1. A01 小椋
  2. A01 高橋(秀)
  3. A01 高橋(智)
  4. A01 道上
  5. A01 檜井
  6. A01 湊元
  7. A01 二川
  8. A01 茶谷
  9. A01 川上
  10. A01 秋山
  11. A01 冨田
  1. A02 篠原
  2. A02 三枝
  3. A02 前川
  4. A02 安部
  5. A02 大神
  6. A02 河野
  7. A02 高野
  1. A03 鈴木
  2. A03 中村
  3. A03 原田
  4. A03 小林
  5. A03 宮本
  6. A03 舟山
  7. A03 柿沼
  1. B01 ラザルス
  2. B01 加藤
  3. B01 國枝
  4. B01 北宅
  5. B01 沢野
研究課題名 低体温誘導の記憶へのリスクと可塑性
研究代表者
Michael Lazarus
  • ラザルス・ミハエル Michael Lazarus
    筑波大学 国際統合睡眠医科学研究機構・准教授 主任研究者
    Website
    http://www.wpiiiislazaruslab.org
連携研究者
  • 坂口 昌徳
    筑波大学 国際統合睡眠医科学研究機構・准教授 主任研究者

Hypothermia caused by hibernation, suspended animation, therapeutic hypothermia or cold environment has been suspected to adversely affect memory function, but the mechanisms linking body temperature and memory formation are poorly defined (Fig. 1). We discovered that activation of neurons in the preoptic area induces hypothermia and impairs fear memory. Therefore, we are investigating how the preoptic area neurons regulate the formation and consolidation of memories in the amygdala or hippocampus. We use intraperitoneal telemetry implants for the thermal detection of body temperature changes. Moreover, we determine “freezing” behavior after fear conditioning by foot shock as a measure of the memory of a traumatic event or the ability of mice to navigate in a water or radial arm maze as a measure of spatial memory. Specifically, we are investigating by using chemogenetic methods and in-vivo Ca imaging whether preoptic area neurons control fear memories in the amygdala, a well-known center in the brain for the expression of fear. We are also investigating whether the expression of fear can also be suppressed by pharmacologically or physically cooling the body of mice (e.g. hypothermia-inducing drugs or cold environment). Finally, we are investigating the risk of chemogenetic activation of preoptic area neurons or body cooling for hippocampus-dependent (i.e. spatial) memories.