Outline of our Research
Today it is possible for mankind to spend more than six months in Outer Space on the International Space Station. The next challenging steps include human exploration to Mars, new missions to the Moon, and living in Space permanently remains a future challenge. Many countries from around the world are participating in global research efforts towards this goal.
How much plasticity can living organisms have in the extreme environment of Space? Are there synergistic interactions among extreme stresses generated during a stay in Space? These questions must be answered before humanity can embark on an extended journey further into Space.
In this Scientific Research on Innovative Areas, we explore the science of plasticity that organisms possess and plasticity collapse in the extreme environment of Space. The plasticity of life may be translated as homeostasis or exemplified by adaptation, repair capabilities, and robustness that organisms possess against external environmental changes, whereas collapse indicates irreversible damage that ruins plasticity, which can be a serious risk of a prolonged stay in Space. As examples of various extreme environmental risks that humans may encounter in Space, our teams of interdisciplinary researchers primarily discuss the environmental risks of zero gravity, confinement, cosmic radiation, and microorganisms. Integrating our findings at various levels from molecular and cellular levels to higher-order control of human activities will help unravel the unknown domains of science, including the interactions and complex effects of different kinds of environmental risks. Furthermore, our goal includes applying our findings to strategies against a hyper-aging and hyper-stressful society on Earth.
The academic goal of this research is to examine the plasticity that organisms possess and its collapse in the extreme environment of Space. The following chart depicts our organizational structure.
Our research groups are divided into three main categories: A01, A02, and A03. Category A01 focuses on the molecular and cellular foundations of gravity responses in cells and small model animals. Category A02 studies the impact of a space environment on the higher-order homeostasis of, primarily, humans. Category A03 focuses on space environmental risks, such as cosmic radiation, changes in microbial flora, etc. These efforts are undertaken by the Programmed and Proposed Research.
The research management group promotes research in an integrated manner, and is composed of the following members:
|Name||Position and Organization|
|Satoshi Furukawa||Senior Researcher Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency|
|Keiji Naruse||Professor, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University|
|Atsushi Higashitani||Professor, Graduate School of Life Sciences, Tohoku University|
|Atsuko Sehara-Fujisawa||Professor, Institute for Frontier Medical Sciences, Kyoto University|
|Kenichi Iwasaki||Professor, School of Medicine, Nihon University|
|Hironobu Morita||Professor, Graduate School of Medicine, Gifu University|
|Ichiyo Matsuzaki||Professor, Faculty of Medicine, University of Tsukuba|
|Hiroshi Nagase||Professor, International Institute for Integrative Sleep Medicine, University of Tsukuba|
|Mitsuru Nenoi||Program Leader, Research Center for Radiation Protection, National Institute of Radiological Sciences (NIRS)|
|Akihisa Takahashi||Professor, Gunma University Heavy Ion Medical Center (GHMC), Gunma University|
|Masao Nasu||Visiting Professor, Faculty of Pharmacy, Osaka Ohtani University|
|Jun Hidema||Associate Professor, Graduate School of Life Sciences, Tohoku University|
|Akira Higashibata||Associate Senior Researcher, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency|
|Toru Shimazu||Senior Researcher, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency|
|Tadashi Murai||Adviser, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency|
|Keiji Murakami||Senior Researcher, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency|