Identification of the gravity sensory system in bone homeostasis in medaka – Publicly Invited Research

  1. A01 Akiyama
  2. A01 Ochi
  3. A01 Chatani
  4. A01 Seiki
  5. A01 Nikawa
  6. A01 Kawakami
  7. A01 Tomita
  8. A01 Honda
  1. A02 Shinohara
  2. A02 Maekawa
  3. A02 Ohgami
  4. A02 Nishimura
  5. A02 Kawano
  6. A02 Iwase
  7. A02 Furuichi
  8. A02 Myung
  9. A02 Kitamura
  1. A03 Nakamura
  2. A03 Harada
  3. A03 Ide
  4. A03 Shirai
  5. A03 Kakinuma
  1. B01 Lazarus
  2. B01 Miwa
  3. B01 Kunieda
  4. B01 Shimada
  5. B01 Kitaya
  6. B01 Sawano
Research Subject Identification of the gravity sensory system in bone homeostasis in medaka
Research Group Leader
Masahiro Chatani
  • Masahiro Chatani
    Assistant Professor, Department of Pharmacology, School of Dentistry, Showa University
Research Collaborator(s)
  • Akira Kudo
    Professor, School of Life Science and Technology, Tokyo Institute of Technology

It is important for organisms to maintain homeostasis on the ground. The microgravity environment has various effects on human health. For example, astronauts undergo a significant decrease in bone mineral density during a space mission, but the precise molecular mechanisms responsible for such changes in bone structure are unclear. To study bone homeostasis, we have established osteoclast- and osteoblast-specific medaka transgenic lines, and conducted two experiments in the International Space Station (Chatani et al. Sci Rep 2015, Chatani et al. Sci Rep 2016). Our results showed the activation of osteoclasts and an increased mRNA expression level of glucocorticoid-related genes. Due to the outcome in space experiments, we plan to develop research on bone homeostasis regulated by gravity.